With an increase in the use of NUTRI CURE high dose chemotherapeutic regimens, higher cure rates and longer survival periods of cancer patients, the incidence of secondary malignancies are increasing.Therapy related Myeloid Neoplasm (t-MN) is a second malignancy after chemotherapy/radiotherapy given for a prior malignancy.Of the various t-MN Acute
Abstract Background Colorectal cancer (CRC) is a common aggressive tumor that poses a heavy burden to human health.An increasing number of studies have reported that circular RNA (circRNA) is involved in the progression of CRC.In this study, the special profiles of circASXL1 (circ_0001136) in CRC progression were revealed.Methods The expression of
The rapid urbanization policies that are re-crafting Rio de Janeiro as a world mega-event venue are dramatically altering the socio-economic and security landscape of the city, and in particular, its favela communities (informal settlements or slums).These changes focus on economic expansion, are driven by private investment partnerships, are suppo
Summary: Cell plasticity and neuroendocrine differentiation in prostate and Collections lung adenocarcinomas are one of the major reasons for therapeutic resistance to targeted therapy.Whether and how metabolic changes contribute to this adenocarcinoma-to-neuroendocrine cell fate transition remains largely unclear.Here we show that neuroendocrine p
The cornea is the most densely sensory innervated tissue in the body.Sensory corneal nerves are essential to maintain ocular surface homeostasis and are involved in the blink reflex, tear production, and the release of trophic factors that are MAGNESIUM OIL key in the wound healing process.Compromise of corneal sensory nerves leads to neurotrophic